17.beta.-Ethynyl-3,17.alpha.-estradiol and derivatives thereof

Details 17.beta.-Ethynyl-3,17.alpha.-estradiol and derivatives thereof 17.beta.-Ethynyl-3,17.alpha.-estradiol and derivatives thereof

1973-09-04

1976-09-28

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603974, 2603975, 424243, C07J 100

Patent

active

039831124

ABSTRACT:
17.beta.-ethynyl-3,17.alpha.-estradiol and derivatives thereof are prepared by epimerization of 17-acyl esters of 17.alpha.-ethynyl-3,17.beta.-estradiol 3-ethers. 17.beta.-ethynyl-3,17.alpha.estradiol and its derivatives are active as post-coital antifertility agents and inhibit the growth of or reduce the size of the prostate gland and the seminal vesicle.

REFERENCES:
Engelfried et al. -- Arzneimittel Forschung, vol. 16, pp. 1518-1521 (1966).
Rodds -- Chemistry of Carbon Compounds, vol. II, Part D, 2nd Ed. (1970), pp. 304 & 307.

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