17-azolyl steroids useful as androgen synthesis inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514172, 540 96, 540 94, 552601, 552602, A61K 3158, C07J 4300, C07J 1700

Patent

active

059943351

ABSTRACT:
Androgen synthesis inhibitors, as well as methods for the use of the same to reduce plasma levels of testosterone and/or dyhydrotestosterone, and to treat prostate cancer and benign prostatic hypertrophy, are disclosed.

REFERENCES:
patent: 5264427 (1993-11-01), Brodie et al.
patent: 5604213 (1997-02-01), Barrie et al.
patent: 5721227 (1998-02-01), Melloni et al.
Pelc et al., Coll. Czech. Chem. Comm. vol. 34, 1969., pp. 442-450.
Petrow et al., The Prostate Cell., 1981., pp. 283-297.
Njar et al, Bioorganic & Medicinal Chemistry Letters, 6(22):2777-2782 (1996).
Njar et al, Steroids, 62:468-473 (1997).
Li et al, J. Med. Chem., 39:4335-4339 (1996).
Angelastro, M.R., et al. "17.beta.-(Cyclopropylamino)-Androst-5-En-.beta.-lkm A Selective Mechanism-Based Inhibitor of Cytochrome P450.sub.17.alpha. (Steroid 17-.alpha.-Hydroxylase/C.sub.17-20 Lyase)", Biochem. Biophys. Res. Commun. 162:1571-1577, 1989.
Ayub, M. et al. "Inhibition of Testicular 17.alpha.-Hydroxylase and 17,20-Lyase but not 3.beta.-Hydroxysteroid Dehydrogenase-Isomerase or 17.beta.-Hydroxysteroid Oxidoreductase by Ketoconazole and Other Imidazole Drugs" J. Steroid Biochem. 28:521-531, 1987.
Banks, P.K. et al. "Regulation of Ovarian Steroid Biosynthesis by Estrogen during Proestrus in the Rat" Endocrinology 129:1295-1304, 1991.
Barrie, S.E. "Inhibition of 17.alpha.-Hydroxylase/C17-C20 Lyase by Bifluranol and its Analogues" J. Steroid Biochem. 33:1191-1195, 1989.
Brodie, A.M.H. et al., "Studies on the Mechanism of Estrogen Biosynthesis in the Rat Ovary-1" J. Steroid Biochem. 7:787-793, 1976.
Brodie, A.M.H. et al., "Inactivation of Aromatase In vitro by 4-Hydroxy-4-Androstene-3, 17-Dione and 4-Acetoxy-4-Androstene-3, 17-Dione and Sustained Effects in vivo" Steroids, 38:693-702, 1981.
Brodie, A.M.H., et al. "Lack of Evidence for Aromatase in Human Prostatic Tissues: Effects of 4-Hydroxyandrostenedione and Other Inhibitors on Androgen Metabolism" Cancer Research, 49:6551-6555, 1989.
Brodie, A.M.H. "Inhibitors of Steroid Biosynthesis" (Ch. 16). in Design of Enzyme Inhibitors as Drugs, vol. 2, (Eds) M. Sandler and H.J. Smith, Oxford University Press, pp. 503-522, 1993.
Brodie, A.M.H. "Steroidogenesis Pathway Enzymes--Introduction"(Ch. 9) in Design of Enzyme Inhibitors as Drugs vol. 2, (Eds) M. Sandler and H.J. Smith, Oxford University Press, pp. 1-13, 1993.
Brodie, A.M.H. "Steroidogenesis Pathway Enzymes--Aromatase Inhibitors" (Section 9B) in Design of Enzyme Inhibitors as Drugs vol. 2, (Eds) M. Sandler and H.J. Smith, Oxford University Press, pp. 424-438, 1993.
Bruchovsky, N. et al. "The Conversion of Testosterone to 5 .alpha.-Androstan-17.beta.-of-3-one by Rat Prostate in Vivo and in Vitro" J. Biol. Chem. 243:2012-2021, 1968.
Bulun et al., "Use of Tissue-Specific Promoters in the Regulation of Aromatase Cytochrome P450 Gene Expression in Human Testicular and Ovarian Sex Cord Tumors, as well as in Normal Fetal and Adult Gonads" J. Clin. Endocrinol. Metab. 77:1616-1621, 1993.
Chomczynski, P. et al. "Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction" Anal. Biochem. 162:156-159, 1987.
Church, G.M. et al. "Genomic Sequencing" Proc. Soc. Natl. Acad. Sci. 81:1991-1995, 1984.
Cohen, S.M. et al. "Comparison of the Effects of New Specific Azasteroid Inhibitors of Steroid 5.alpha.-Reductase on Canine Hyperplastic prostate: Suppression of Prostatic DHT Correlated with prostate Regression" The Prostate 26:5571, 1995.
Coen, P., et al. "An Aromatase-Producing Sex-Cord Tumor Resulting in Prepubertal Gynecomastia" New Eng. J. Med. 324:317-322, 1991.
Coombes, R.C. et al. "4-Hydroxy Androstenedione Treatment for Postmenopausal Patients with Advanced Breast Cancer" Steroids 50:245-252, 1987.
Covey, D.F. et al., "10.beta.-Propynyl-substituted Steroids" J. Biol. Chem., 256:1076, 1980.
Crawford, E.D. et al. "A Controlled Trial of Leuprolide with and without Flutamide in Prostatic Carcinom" N. Engl. J. Med., 321-419-424, 1989.
di Salle, E. et al. "Effects of 5.alpha.-Reductase Inhibitors on Intraprostatis Androgens in the Rat" J. Steroid Biochem. Mol. Biol., 53, 1-6:381-385, 1995.
Doorenbos, N.J. et al. "17.beta.-Isoxazolyl and 17.beta.-Pyrazolyl Steroids from 3.beta.-Hydroxy-21-formylpregn-5-en-20-one." J. Org. Chem. 31:3193, 1966.
Forti, G., et al. "Three-Month Treatment with a Long-Acting Gonadotropin-Releasing Hormone Agonist of Patients with Benign prostatic Hyperplasia: Effects on Tissue Androgen Concentration, 5.alpha.-Reductase Activity and Androgen Receptor Content" J. Clin. Endocrinol. Metal. 68:461-468, 1989.
Frye, S. et al. "6-Azasteroids; Potent Dueal Inhibitors of Human Type 1 and 2 Steroid 5.alpha.-Reductase" J. Med. Chem. 36:4313-4315, 1993.
Gaddipati, J.P. et al. "Frequent Detection of Codon 877 Mutation in the Androgen Receptor Gene in Advanced Prostate Cancers" Cancer Res. 54:2861-2864, 1994.
Geller, J. et al. "Comparison of Prostatic Cancer Tissue Dihydrotestosterone Levels at the Time of Relapse Following Orchiectomy or Estrogen Therapy" J. Urology 132:693-696, 1984.
Gold, R. et al. "Detection of DNA Fragmentation in Apoptosis: Application of in situ Nick Translation to Cell Culture Systems and Tissue Sections" J. Histochem. Cytochem. 41,7:1023-1030, 1993.
Goldman, A.S. et al. "Production of Male Pseudohemaphroditism in Rats by Two New Inhibitors of Steroid 17.alpha.-hydroxylase and C17-20 Lyase" J. Endoc. 71:289, 1976.
Gormley, G.J. "Role of 5.alpha.-Reductase Inhibitors in the Treatment of Advanced Prostatic Carcinoma" Urol. Clinics of North America 18, 1:93-97, 1991.
Goss, P.E. et al. "Treatment of Advanced Postmenopausal Breast Cancer with an Aromatase Inhibitor, 4-Hydroxyandrostenedione: Phase II Report" Cancer Res. 46:4223-4826, 1986.
Goya, S. et al. "Studies on Cardiotonic Steroid Analogs" Yakugaku Zasshi., 90:537, 1970.
Haaase-Held, M., et al. "The Synthesis of 4-Cyanoprogesterone: A Potent Inhibitor of the Enzyme 5-.alpha.-Reductase" J. Chem. Soc. Perkin Trans. 1:2999, 1992.
Habernicht, U.F. et al. "Induction of Estrogen-Related Hyperplastic changes in the Prostate of the Cynomolgus Monkey (Macaca fascicularis) by Androstenedione and its Antagonization by the Aromatase Inhibitor 1-Methyl-Androsta-1, 4-Diene-3, 17-Dione" Prostate, 11:313-326, 1987.
Haffner, "Synthesis of 6-Azacholesten-3-ones:Potent Inhibitors of 5.alpha.-Reductase"; Tetrahedron Letters 36:4039-4042, No. 23, 1995.
Hamilton, G.A. "Chemical Models and Mechanisms for Oxygenases" in "Molecular Mechanism of Oxygen Activation"; Hayishi, O., Ed.; Academic Press: New York: 405, 1974.
Harada, "Novel Properties of Human Placental Aromatase as Cytochrome P-450: Purification and Characterization of a Unique Form of Aromatase", J. Biochem 103:106-113 (1988).
Henderson, D. "Estrogens and Benign prostatic Hyperplasia: Rationale for Therapy with Aromatase Inhibitors" Annals med. 23:201-203, 1991.
Hoehn, W., et al. "Human Prostatis Adenocarcinoma:Some Characteristics of a Serially Transplantable Line in Nude Mice (PC82)" Prostate 1:94-104, 1980.
Holt, D.A. et al. "Inhibition of Steroid 5.varies.-Reductase by Unsaturated 3-Carboxysteroids" J. Med. Chem. 33:943-950, 1990.
Hsiang, Y.H.H. et al. "The influence of 4-Hydroxy-4-Androstene-3, 17-Dione on Androgen Metabolixm and Action in Cultured Human Foreskin Fibroblasts" J. Steroid Biochem. 26:131-136, 1987.
Huynh, C. et al. "Fixation d'un Groupe Nitrile en Position 4 des Ceto-3.sub..DELTA..sup.4 -steroides" Bull. Soc. Chim. Fr.:4396, 1971.
Inkster et al "Human Testicular Aromatase:Immunocyctochemical and Biochemical Studies" J. Clin. Endocrinol. Metab. 80:1941-1947, 1995.
Ishibashi, K. et al. "Synthesis of B-NOR-4-AZA-5.alpha.-Androstane Compound as 5.alpha.-Reductase Inhibitor" Bioor. & Med. Lett., 4:729-732, 1994.
Jarman, M. et al. "Hydroxyperfluorozobenzenes: Novel Inhibitors of Enzymes of Androgen Biosynthesis" J. Med. Chem. 33:2452-2455, 1990.
Kitz, R. et al., "Esters of Methanesulfonic Acid as Irreversible Inhibitors of Acetylcholinesterase" J. Biol. Chem. 237: 3245-3249, 1962.
Klus, G. et al. "Growth Inhibition of Human Prostate Cells in vitro by Novel Inhibitors of Andro

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

17-azolyl steroids useful as androgen synthesis inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 17-azolyl steroids useful as androgen synthesis inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 17-azolyl steroids useful as androgen synthesis inhibitors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1672754

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.