17-aryl-substituted steroidal compounds active on the cardiovasc

Details 17-aryl-substituted steroidal compounds active on the cardiovasc 17-aryl-substituted steroidal compounds active on the cardiovasc

1993-01-15

1995-06-13

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514182, 536 5, 536 6, 540108, 540113, 552612, 552616, 552633, 552636, 552641, C07J 100, C07J 4300

Patent

active

054243041

ABSTRACT:
Cardioactive steroidal compounds of the formula I ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 have the meanings shown in the description, and pharmaceutical compositions containing them.

REFERENCES:
K. R. H. Repke, TIPS-(Jul. 1985), Elsevier Science Publishers, BV Amsterdam, pp. 275,278, "New Developments in Cardia Glycoside".
Uttam K. Pati et al, Heterocycles, 29 (7), pp. 1275-1282 (1989) "Synthesis of 5.beta.-Androstan-17.beta.-(1'Oxocyclohex-1'-EN-3'-YL) . . . ".
J. C. Beloeil et al, Tetrahedron 39 (23), pp. 3937-3941 (1983) "Synthetic Studies in the Cardenolide Series--II, . . . ".
O. Mitsunobu, Synthesis, 1, (1981), "The Use of Diethyl Azzodicarboxylate and Triphenylphosphine in Synthesis and . . . ".
Richard R. Schmidt, Agnew. Chem. Int. Ed. Engl., 25, (1986), pp. 212-235, "New Methods for the synthesis of Glycosides . . . ".
Hans Paulsen, Agnew. Chem. Int. Ed. Engl., 21, (1982) pp. 155-173, "Advances in Selective Chemical Synthesis of . . . ".
Karel Wiesner et al, Helv. Chim. Acta, 68, (1985), pp. 300-314 "On Cardioactive Steroids. XVI. Stereoselective .beta.-Glycosylation."
F. Noel et al, Biochemical Pharmacology, 40 (12), pp. 2611-2616 (1990), "A Comparision of the Affinities of Rate (Na.sup.+ +K.sup.+)-. . . ".

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