17.alpha.-(substituted-methyl)-17.beta.-hydroxy/esterified hydro

Details 17.alpha.-(substituted-methyl)-17.beta.-hydroxy/esterified hydro 17.alpha.-(substituted-methyl)-17.beta.-hydroxy/esterified hydro

1986-09-17

1988-09-27

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514179, 26039745, 540 94, 540 95, 540107, 540108, A61K 3158, A61K 3156, C07J 100, C07J 4300

Patent

active

047742364

ABSTRACT:
Steroids of the formula: ##STR1## which are characterized by a 17.alpha.-cyanomethyl, azidomethyl, methoxymethyl, phenylmethyl, or ethynylmethyl substituent and a 17.beta.-hydroxy/esterified hydroxy substituent. The steroids of this invention have glucocorticoid, anti-glucocorticoid, progestational, or anti-progestational activity, depending on the particular structure.

REFERENCES:
patent: 4233296 (1980-11-01), Teutsch et al.
patent: 4447424 (1984-05-01), Teutsch et al.
patent: 4536401 (1985-08-01), Neef et al.
patent: 4540686 (1985-09-01), Philibert et al.
Chemical Abstracts; vol. 103 (1985); #6617y; Neef et al.
Chemical Abstracts, Issue 1, (1988), #6285s; Philibert et al.

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