Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1976-08-12
1977-12-27
Killos, Paul J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
2603457P, 2603458P, 2603473, 2603479, 424305, 424308, 424317, 260516, 260520R, 260520C, 542426, C07C 6976
Patent
active
040656322
ABSTRACT:
The present invention relates to compounds of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## B represents an oxygen or sulphur atom, R.sup.1 and R.sup.2, which may be the same or different, each represent a hydrogen or halogen atom, a trifluoromethyl group, or a straight- or branched-chain alkyl or alkoxy group containing from 1 to 4 carbon atoms, R represents a group of the formula --COOR.sup.3, in which R.sup.3 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, or a group of the formula --CH.sub.2 OR.sup.4, in which R.sup.4 represents a hydrogen atom or an alkylcarbonyl group containing from 2 to 5 carbon atoms and the double bonds depicted in positions C.sub.2 -C.sub.3, C.sub.5 -C.sub.6 and C.sub.13 -C.sub.14 are trans, cis and trans respectively, the cyclodextrin clathrates thereof and, when R.sup.3 in the group --COOR.sup.3 represents a hydrogen atom, non-toxic salts thereof. These compounds exhibit characteristics of prostaglandin-like activity.
REFERENCES:
derwent Abst. 46497 w/28, 3/7/75.
Derwent Abst. 73279 U-B, 10/5/72.
Hayashi Masaki
Kori Seiji
Miyake Hajimu
Okada Takanori
Chow Frank S.
Graddis Albert H.
Killos Paul J.
Ono Pharmaceutical Company
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