16-Phenoxy and 16-substituted phenoxy-prostatrienoic acid deriva

Details 16-Phenoxy and 16-substituted phenoxy-prostatrienoic acid deriva 16-Phenoxy and 16-substituted phenoxy-prostatrienoic acid deriva

1975-12-22

1976-10-12

Killos, Paul J.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260240R, 26029365, 2603432R, 2603457, 2603458, 2603462R, 2603473, 2603474, 2604299, 2604381, 260439R, 260448R, 2605011, 26050111, 26050117, 260520B, 424308, 424317, C07C 6976

Patent

active

039857913

ABSTRACT:
Novel racemic and 8R-antimeric 16-phenoxy- and 16-(o, m or p)-substituted phenoxy derivatives of 9.alpha., 11.alpha.,15-trihydroxy-17,18,19,20-tetranorprosta-4,5,13-trans-trienoic acids, which may be further substituted at C-15 by a methyl or ethyl group, the pharmaceutically acceptable, non-toxic lower alkyl esters and salts thereof and processes for the production of such compounds. dl 9.alpha.,11.alpha.,15.alpha.-trihydroxy-16-m-trifluoromethylphenoxy-17,18, 19,20-tetranorprosta-4,5,13-trans-trienoic acid and dl 9.alpha.,11.alpha.,15 -trihydroxy-15 -methyl-16-m-trifluoromethylphenoxy-17,18,19,20-tetranorprosta-4,5,13-tran s-trienoic acid are representative compounds of the class. These compounds possess prostaglandin-like activities and thus are useful in the treatment of mammals where prostaglandins are indicated. They are particularly useful as luteolytic agents in female mammals.

REFERENCES:
patent: 3873598 (1975-03-01), Crabbe et al.
patent: 3879438 (1975-04-01), Crabbe et al.
Binder, D. et al., Prostaglandins, vol. 6, No. 1, Apr. 10, 1974, pp. 87-90.
Dawson, W. et al., Nature, vol. 250, July 26, 1974, pp. 331-332.
Annales de Biologie Animale Biochimie Biophysique, vol. 15, (2), pp. 161-174 and pp. 383-384.

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