16-METHYLENE-PROSTAGLANDIN COMPOUNDS

Details 16-METHYLENE-PROSTAGLANDIN COMPOUNDS 16-METHYLENE-PROSTAGLANDIN COMPOUNDS

1976-05-13

1977-04-19

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603457, 2603458, 2603473, 2603474, 2604488R, 260488R, 260514D, 536 1, 424305, 424317, C07C17700

Patent

active

040188124

ABSTRACT:
A compound of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## , R.sup.1 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 6 carbon atoms, R.sup.2 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, X represents trans-vinylene or ethylene, and the wavy line indicates attachment of the hydroxy radical in .alpha.- or .beta.-configuration and cyclodextrin clathrates thereof and, when R.sup.2 represents a hydrogen atom, non-toxic salts thereof. These compounds exhibit characteristic prostaglandin activity.

REFERENCES:
patent: 3953495 (1976-04-01), Hayashi et al.

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