Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai
Patent
1998-07-31
2000-02-29
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
9,10-seco- cyclopentanohydrophenanthrene ring system doai
552653, A01N 4500, C07C40100
Patent
active
060309636
ABSTRACT:
The invention relates to a compound of the formula ##STR1## wherein A is ##STR2## Et is ethyl, and R is hydroxy and R.sup.1 is hydrogen or .dbd.CH.sub.2 or R is hydrogen or fluoro and R.sup.1 is .dbd.CH.sub.2. Compounds of formula I stimulate HL-60 cell differentiation. Accordingly, the compounds of formula I are useful as agents for the treatment of neoplastic diseases, such as leukemia.
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Iacobelli Jerome Anthony
Uskokovic Milan Radoje
Dees Jos,e G.
Hoffmann-La Roche Inc.
Johnston George W.
Pryor Alton
Rocha-Tramaloni Patricia S.
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