16-Chloro-substituted prostaglandins and derivatives thereof

Details 16-Chloro-substituted prostaglandins and derivatives thereof 16-Chloro-substituted prostaglandins and derivatives thereof

1976-07-29

1978-01-17

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

2603458P, 2604488R, 260514D, 260586R, 260617R, 424305, 424317, 536112, 542426, C07C17700

Patent

active

040693872

ABSTRACT:
The present invention relates to compounds of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## B represents a single bond or a straight- or branched-chain alkylene group containing from 1 to 9 carbon atoms, W represents ethylene or trans-vinylene, X represents ethylene or cis-vinylene, Y represents ethylene or trans-vinylene, R represents a hydroxymethyl group or a grouping of the formula --COOR.sup.4, in which R.sup.4 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, R.sup.1 represents a hydrogen atom or a methyl or ethyl group, R.sup.2 represents a hydrogen atom or a methyl or ethyl group and R.sup.3 represents a hydrogen or chlorine atom or a hydroxy group and cyclodextrin clathrates of such alcohols, acids and esters and, when R.sup.4 in the formula --COOR.sup.4 represents a hydrogen atom, non-toxic salts thereof, and intermediates therefor. These compounds exhibit characteristic prostaglandin-like activity.

REFERENCES:
patent: 3962293 (1976-06-01), Magerlin
patent: 4024174 (1977-05-01), Hayashi et al.

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