16.beta.-Methyl steroid process

Details 16.beta.-Methyl steroid process 16.beta.-Methyl steroid process

1983-02-09

1984-05-29

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603971, C07J 100, C07J 900

Patent

active

044514042

ABSTRACT:
.DELTA..sup.4 -3-keto, .DELTA..sup.1,4 -3-keto and 3.beta.-hydroxy 17-keto steroids (I) are transformed into the corresponding 16-.beta.-methyl-17-keto steroids (IV) by first activating the C-16 position, then methylating. By protecting the C-3 position of the .DELTA..sup.4 -3-keto and 3.beta.-hydroxy steroids the yields are greatly increased.

REFERENCES:
patent: 3039528 (1962-06-01), Arth et al.
patent: 3704253 (1972-11-01), Stein et al.
patent: 4216159 (1980-08-01), Hessler et al.
P. de Ruggieri et al., Gazz Chim. Ital., vol. 91, p. 672, (1961).
G. Neef et al., J. Org. Chem., vol. 43, p. 4679, (1978).

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