16.alpha.-methylated.DELTA.17(20)-corticoids

Details 16.alpha.-methylated.DELTA.17(20)-corticoids 16.alpha.-methylated.DELTA.17(20)-corticoids

1985-04-18

1987-11-03

Schenkman, Leonard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

2603973, 26039747, 2603975, C07J 100

Patent

active

047044551

ABSTRACT:
C.sub.16 -unsaturated corticoids are readily transformed to the corresponding 16.alpha.-methyl-17.alpha.-hydroxy corticoids by use of a .DELTA..sup.17 (.sup.20)-20-silyl ether.

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Organic Reactions in Steroid Chemistry, vol. II, J. Fried and J. A. Edwards, Van Nostrand Reinhold Co., NY 1972, pp. 75-76.
J. Am. Chem. Soc. 80, 3160-3161 (1958).
J. Am. Chem. Soc. 80, 4428 (1958).

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