16.alpha. Halogen substituted 3,17.beta.-dihydroxy steroidal est

Details 16.alpha. Halogen substituted 3,17.beta.-dihydroxy steroidal est 16.alpha. Halogen substituted 3,17.beta.-dihydroxy steroidal est

1980-04-09

1984-08-14

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2603975, 422 61, A01N 4500

Patent

active

044656769

ABSTRACT:
16.alpha.-Radiohalo-3,17.beta.-dihydroxy steroidal estrogens and their radiolabelled analogs are described. These steroidal estrogens have high estrogen receptor activity and are prepared by halogen exchange with the corresponding 16.beta.-bromo compound. The radiolabelled estrogens of this invention are useful in estrogen receptor assays, radioimmunoassays, in vivo imaging of tissue having estrogen receptor activity, and for therapeutic treatment of tumors having estrogen receptor activity.

REFERENCES:
patent: 2855413 (1958-10-01), Mueller
Ghanadian et al., "International Journal of Applied Radiation and Isotopes", (1975), vol. 26, pp. 343-346.
Arunachalam et al., J. Biol. Chem. 254, (1979), pp. 5900-5905.

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