16-Alkyl-1,4,9(11)-pregnatrienes and 9,11-epoxides thereof

Details 16-Alkyl-1,4,9(11)-pregnatrienes and 9,11-epoxides thereof 16-Alkyl-1,4,9(11)-pregnatrienes and 9,11-epoxides thereof

1974-10-11

1976-03-30

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26039745, 2602395, C07J 700, C07J 100

Patent

active

039474097

ABSTRACT:
The invention disclosed herein relates to processes and intermediates useful in the preparation of certain 16-lower alkyl-1,4-pregnadiene compounds. It is particularly concerned with novel methods of preparing 16-lower alkyl-9.alpha.-fluoro-11.beta.,17.alpha.,21-trihydroxy-1,4-pregndiene-3,20 -dione and esters thereof, and with novel intermediates useful in these novel methods. It is further concerned with 16-lower alkyl-1,4,9(11)-pregnatriene-17.alpha.,21-diol-3,20-diones and their 21-lower alkanoates which, in addition to being valuable as intermediates, are valuable diuretic agents useful in the treatment of edema.

REFERENCES:
patent: 3164618 (1965-01-01), Rausser et al.

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