16,17-Pyrazolino- and 16,17-isopyrazolino-1,4-pregnadiene deriva

Details 16,17-Pyrazolino- and 16,17-isopyrazolino-1,4-pregnadiene deriva 16,17-Pyrazolino- and 16,17-isopyrazolino-1,4-pregnadiene deriva

1978-11-30

1980-11-04

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602395, 26039745, A61K 3158, C07J 4300

Patent

active

042320135

ABSTRACT:
New 16,17-pyrazolino- and 16,17-isopyrazolino-1,4-pregnadiene-derivatives have been prepared, useful as antiinflammatory agents on topical and/or systemic administration. An analogy process for the preparation of 16,17-pyrazolino-1,4-pregnadiene derivatives and the quite surprising conversion of the latter ones to 16,17-isopyrazolino-1,4-pregnadiene derivatives are also disclosed. The results of pharmacological comparative trails of some new products of the present invention v. fluocinolone acetonide are reported.

REFERENCES:
patent: 3350394 (1967-10-01), Agnello et al.
patent: 3384637 (1968-05-01), Diassi
patent: 3538130 (1970-11-01), Hewett et al.
Taub et al., Journ. Oreg. Chem. 29 (1964) pp. 3486-3495.

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