Organic compounds -- part of the class 532-570 series – Organic compounds – Cyclopentanohydrophenanthrene ring system containing
Reexamination Certificate
2011-01-11
2011-01-11
Padmanabhan, Sreeni (Department: 1627)
Organic compounds -- part of the class 532-570 series
Organic compounds
Cyclopentanohydrophenanthrene ring system containing
C552S514000, C514S169000, C514S178000, C514S182000
Reexamination Certificate
active
07868193
ABSTRACT:
The invention discloses a steroid compound having the formula (1), wherein dotted bonds represent optional double bonds; R6is H, ═CH2, or —CH3, or —CH2—CH3; R7is H, C1-4-alkyl, C2-5alkenyl or C2-5-alkynyl, wherein the alkyl, alkenyl or alkynyl group may be substituted with 1 to 3 halogen atoms independently chosen from the group of fluorine or chlorine atoms; R11is H, C1-4-alkyl, C2-4-alkenyl, C2-4-alkynyl or C1-4-alkylidene, wherein the alkyl, alkenyl, alkynyl or alkylidene group may be substituted with 1-3 halogen atoms independently chosen from the group of fluorine or chlorine atoms; E represents together with carbon atoms 16 and 17 of the steroid skeleton a four to seven-membered ring, said ring being α and in cis-configuration with respect to the steroid skeleton, optionally comprising one or two endocyclic bonds; or a prodrug thereof. Such compounds can be used in therapy and for methods for selective modification of the activity of estrogen receptors.
REFERENCES:
patent: 3194821 (1965-07-01), Freiberg et al.
patent: 0798378 (1997-10-01), None
patent: 0 869 132 (1998-10-01), None
J.R. Bull et al: “Synthesis of 14, 17-Propano analogues of estradiol”; Journal of the Chemical Society, Perkin Transactionsl., 1997, pp. 1179-1192.
El Garrouj Driss et al: “Steroidal affinity labels of the estrogen receptor: 1. 17-alpha-(Bromoacetoxy)alky/alkynylestradiols.”; Journal of Medicinal Chemistry, vol. 36, No. 20, 1993, pp. 2973-2983.
Mosselman, et al., “ERβ: Identification and Characterization of a Novel Human Estrogen Receptor,”FEBS Letters, 392, 1996, pp. 49-53.
Wronski, T.J., et al., “The Ovariectomised Rat as an Animal Model for Postmenopausal Bone Loss,”Cells and Materials, Supp. 1, 1991, pp. 69-74.
Yamazaki, I. et al., “Characteristics of an Ovariectomised Osteopenic Rat Model,”J. Bone Min. Res. 4, 1989, pp. 13-22.
Ederveen, A.G.H., et al., “Tibolone, a Steroid with a Tissue-Specific Hormonal Profile, Completely Prevents Ovariectomy-Induced Bone Loss in Sexually Mature Rats,”J. Bone Min. Res. vol. 14, 1999, pp. 1963-1970.
Allen, E. et al., “An Ovarian Hormone,”J. Amer. Med. Assoc., 81, 1923, pp. 819-821.
Camara Valerie J.
Hess Susan L.
Kantamneni Shobha
N.V. Organon
Padmanabhan Sreeni
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