16,16-Dimethyl 9-oxo-11.alpha.-hydroxymethyl-15.epsilon.-hydroxy

Details 16,16-Dimethyl 9-oxo-11.alpha.-hydroxymethyl-15.epsilon.-hydroxy 16,16-Dimethyl 9-oxo-11.alpha.-hydroxymethyl-15.epsilon.-hydroxy

1974-04-03

1977-03-15

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260240R, 2603458, 260413, 260514D, 2603433R, 2604109R, 260463, 424305, 424317, C07C17700

Patent

active

040124290

ABSTRACT:
Prostanoic acid derivatives having the formula ##STR1## wherein A represents a straight or branched alkylene group having from one to 5 carbon atoms, R.sup.1 represents a straight or branched alkyl group having from 4 to 10 carbon atoms and R.sup.2 represents hydrogen atom or a straight or branched alkyl group having from one to 6 carbon atoms and pharmaceutically acceptable salts thereof.
The compounds are useful as oxytocic agents and agents inhibiting the secretion of gastric acid and may be prepared by oxidizing a compound having the formula ##STR2## wherein A, R.sup.1 and R.sup.2 are the same as above, R.sup.3 and R.sup.4 are the same or different and each represents a protecting group for the hydroxyl group to give a compound having the formula ##STR3## wherein A, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same as above, removing the hydroxyl-protecting group from the latter compound and, if appropriate, salifying the product thus obtained.

REFERENCES:
patent: 3816393 (1974-06-01), Hayashi et al.
patent: 3845042 (1974-10-01), Strike et al.
patent: 3849474 (1974-11-01), Abraham et al.
patent: 3931282 (1976-01-01), Muchowski et al.
Robert, Research in Prostaglandins, Worcester Foundation for Experimental Biology, Jan. 1973.
Corey et al., JACS, 92, 397, (1970).

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