15(R)-5-fluoroprostacyclins, pharmaceutical compositions and ant

Details 15(R)-5-fluoroprostacyclins, pharmaceutical compositions and ant 15(R)-5-fluoroprostacyclins, pharmaceutical compositions and ant

1985-02-28

1986-10-07

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514337, 549465, 549269, A61K 31557, C07D307935

Patent

active

046160345

ABSTRACT:
The present invention provides novel compounds of Formula I ##STR1## which are pharmacologically selectively useful as anti-thrombotic agents with minimal blood pressure lowering activity.

REFERENCES:
patent: 4178367 (1979-12-01), Masaki et al.
patent: 4324730 (1982-04-01), Fried
patent: 4540801 (1985-09-01), Nysted et al.
Progress in Medicinal Chem., vol. 21 (1984), Chapter 6, pp. 238-279, by Whittle & Moncada.
Gandolfi et al, "Prostacyclin Analogs: Structure Activity Relationships", Prostaglandins and Cardiovascular Disease, Raven Press, New York, 1981, p. 184.
Flohe et al, Arzneim Forsch/Drug Res., 33(11), No. 9 (1983).

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