15-Oxygenated sterol compounds and the use of such compounds to

Details 15-Oxygenated sterol compounds and the use of such compounds to 15-Oxygenated sterol compounds and the use of such compounds to

1977-05-16

1980-05-13

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424238, 424243, 2603972, A61K 3156, C07J 900

Patent

active

042028914

ABSTRACT:
15-oxygenated sterols, having the ability to inhibit the biosynthesis of mevalonic acid, and produce other effects derived from their ability to inhibit the biosynthesis of mevalonic acid, are disclosed. The 15-oxygenated sterols correspond to the structural formula: ##STR1## where: R.sub.1 is --OH, .dbd.O, --OR.sub.4, ##STR2## a sulfate group, or a Mg, Na, or K salt of a sulfate group; R.sub.2 is --OH, .dbd.O, or ##STR3## R.sub.3 is .alpha.H, .beta.H, or an .alpha.C.sub.1 to C.sub.6 alkyl group; R.sub.r is a C.sub.1 to C.sub.6 alkyl group and preferably a C.sub.1 to C.sub.3 alkyl group;

REFERENCES:
patent: 3287380 (1966-11-01), Miki et al.
patent: 3354154 (1967-11-01), Edwards et al.
Martin et al., "Biochemical and Biophysical Research Communications," vol. 39, No. 6 (1970).
Knight et al., "The Journal of Biological Chemistry," Apr. 10, 1966.

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