15-hydroxy 6,9-hemiacetal erythromycin compounds

Details 15-hydroxy 6,9-hemiacetal erythromycin compounds 15-hydroxy 6,9-hemiacetal erythromycin compounds

1995-06-07

1998-12-29

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514 29, 536 73, 536 74, C07H 1708

Patent

active

058544070

ABSTRACT:
Disclosed are (1) a structurally novel 6,9-hemiacetal- erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions br a salt thereof, which has an excellent gastrointestinal function promoting effect and is low in toxicity; (2) a process for preparing a 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof, which comprises reacting a 6,9-hemiacetal-erythromycin derivative or a salt thereof with an organism-derived oxidase; and (3) a gastrointestinal function promoting agent containing a 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof.

REFERENCES:
patent: 5470961 (1995-11-01), Harada et al.
Tsuzuki, Kazuo, Chem. Pharm. Bull 37 (10) 2687-2700 (1989).
Omura, Satoshi, et al., Journal of Medicine Chem., vol. 30:11 1941-1943 (1987).

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