15-Ethylenedioxy-prostanoic acid derivatives and esters thereof

Details 15-Ethylenedioxy-prostanoic acid derivatives and esters thereof 15-Ethylenedioxy-prostanoic acid derivatives and esters thereof

1975-07-11

1978-05-09

Rosen, Sam

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

2603409P, 424282, 542429, 542430, A61K 31335, A61K 3136, C07D31700

Patent

active

040887758

ABSTRACT:
Prostanoic acid derivatives of the formula ##STR1## wherein R.sub.1 is a hydrogen atom, alkyl of 1-10 carbon atoms, aryl or --CH.sub.2 --U--V wherein U is a direct bond, carbonyl, or carbonyloxy and V is phenyl or substituted phenyl, e.g. substituted by at least one of phenyl, alkoxy of 1-2 carbon atoms or a halogen atom; one of R.sub.2 and R.sub.3 is hydroxy and the other is a hydrogen atom or R.sub.2 and R.sub.3 collectively are an oxygen atom; A is --CH.sub.2 --CH.sub.2 -- or trans--CH.dbd.CH; B is --CH.sub.2 --CH.sub.2 -- or cis--CH.dbd.CH; D and E collectively are a direct bond, or D is alkylene or 1-5 carbon atoms and E is an oxygen or sulfur atom; R.sub.4 is alkyl of 1-10 carbon atoms, alkyl of 1-5 carbon atoms substituted by unsubstituted or substituted aryl, unsubstituted or substituted aryl, or benzodioxol-2-yl-; X--Y is ##STR2## when one of R.sub.2 and R.sub.3 is a hydroxy group and the other is a hydrogen atom or X--Y is ##STR3## or --CH.dbd.CH-- when R.sub.2 and R.sub.3 collectively are an oxygen atom; and when R.sub.1 is a hydrogen atom, the physiologically acceptable salts thereof with bases, have an activity spectrum similar to but stronger and longer lasting activity than the corresponding natural prostaglandins.

REFERENCES:
patent: 3900512 (1975-08-01), Sih
patent: 3962218 (1976-06-01), Raduchel et al.

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