15-Epi-15-methyl-16-phenoxy-PGE compounds

Details 15-Epi-15-methyl-16-phenoxy-PGE compounds 15-Epi-15-methyl-16-phenoxy-PGE compounds

1976-08-16

1979-05-15

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 55, C07C17700

Patent

active

041549503

ABSTRACT:
Prostaglandin E-, F.sub..alpha. -, F.sub..beta. -, A-, and B-type compounds are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they are substituted at C-16 with a phenoxy or substituted phenoxy, and have a lower alkyl group in place of the hydrogen at C-15 and/or a lower alkoxy group in place of the hydroxy group at C-15. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.

REFERENCES:
patent: 4024179 (1977-05-01), Bindra et al.

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