15-deoxyspergualin analogs, their method of preparation and thei

Details 15-deoxyspergualin analogs, their method of preparation and thei 15-deoxyspergualin analogs, their method of preparation and thei

1993-12-02

1995-12-19

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

N-c doai

514588, 514616, 560159, 564 59, 564160, A61K 3127

Patent

active

054768705

ABSTRACT:
The present invention relates, by way of novel industrial products, to compounds which are structurally related to 15-deoxyspergualin. These novel compounds have the formula ##STR1## in which: n is equal to 6 or 8 and
A is a single bond, CH.sub.2, CHF, CH(OH), CH(OCH.sub.3), CH.sub.2 NH or CH.sub.2 O,
and their addition salts.

REFERENCES:
patent: 4956504 (1990-09-01), Takeuchi
Journal of Antibiotics, vol. 41, No. 11, Nov. 1988, Tokyo, Japan, pp. 1629-1643 R. Nishizawa "Synthesis and Biological Activity of Spergualin Analogues I" *p. 1629, lines 9-15; tables 1-2*.

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