15-deoxyspergualin analogs, their method of preparation and thei

Details 15-deoxyspergualin analogs, their method of preparation and thei 15-deoxyspergualin analogs, their method of preparation and thei

1995-02-23

1997-06-10

Conrad, Joseph

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514588, 514619, 514626, 560 33, 564 59, 564160, 564161, 564192, 564201, 564209, A61K 3124, C07C27106, C07C23704

Patent

active

056376138

ABSTRACT:
The present invention relates, by way of novel industrial products, to compounds which are structurally related to 15-deoxyspergualin and which have the formula ##STR1## in which: A is a single bond, a group --CH.sub.2 --, a group --CH.sub.2 O--, a group --CH.sub.2 NH--, a group --CH(OH)--, a group --CHF-- or a group --CH(OCH.sub.3)--, and

REFERENCES:
Int. J. Immunopharmac., vol. 14, No. 4, 1992, pp. 731-737, H. Fuji et al., "Deoxyspergualin, a novel immunosuppressant, markedly inhibits human mixed lymphocyte reaction and cyctotoxic T-lymphocyte activity in vitro".
Journal of Medicinal Chemistry, vol. 35, No. 4, 1992, Washington U.S., pp. 724-734, J. R. Lakanen et al., "Alpha-Methyl polyamines: metabolically stable spermidine and permine mimics capable of supporting growth in cells depleted of polyamines".
Journal of Antibiotics, vol. 41, No. 2, 1988, Tokyo, Japan, pp. 234-238, H. Karamochi et al., "The antiproliferative action of action of deoxyspergualin is different from that induced by amine oxidase".
Journal of Antibiotics, vol. 41, No. 11, Nov. 1988, Tokyo, Japan, pp. 1629-1643, R. Nishizawa et al., "Synthesis and Biological Activity of Spergualin Analogues".

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