15-deoxyspergualin analogs, their method of preparation and thei

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – N-c doai

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560159, A61K 3127

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active

057339287

ABSTRACT:
The present invention relates to a novel compound selected from the group consisting of:
(i) the compounds of the formula ##STR1## in which: A is a group --CO--NH-- or a group --NH--CO--,

REFERENCES:
R. Nishizawa et al., The Journal of Antibiotics, "Synthesis and Biological Activity of Spergualin Analogues" vol. XLI, No. 11, p. 1629-1643. (1988).
Yoshihisa Umeda et al., The Journal of Antibiotics, "Synthesis and Antitumor Activity of Spergualin Analogues", vol. XL, No. 9, pp. 1303-1315, (1987).
Yoshihisa Umeda et al., The Journal of Antibiotics, "Synthesis and Antitumor Activity of Spergualin Analogues I. Chemical Modification of 7-Guanidino-3-hydroxyacyl Moiety", vol. XXXVIII No. 7, pp. 886-898, (1985).
P. S. Almond et al., Annals New York Academy of Sciences, "Rapamycn in a Porcine Renal Transplant Model", pp. 120-201. (1993).

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