15-Cycloalkyl-prostaglandin derivatives

Details 15-Cycloalkyl-prostaglandin derivatives 15-Cycloalkyl-prostaglandin derivatives

1976-07-07

1978-05-02

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

2603457P, 2603458P, 2604488R, 260514D, 260520B, 424305, 424308, 424317, 536103, 560 53, 560 59, 542426, C07C17700

Patent

active

040876209

ABSTRACT:
The present invention relates to 15-cycloalkyl-prostaglandins of the formula: ##STR1## WHEREIN A represents a grouping of the formula: ##STR2## W represents ethylene or trans-vinylene, X represents ethylene or cis-vinylene, Y represents ethylene or trans-vinylene, R represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, R.sup.1 represents a hydrogen atom or a methyl or ethyl group, R.sup.2 represents a straight- or branched-chain alkyl group containing from 2 to 8 carbon atoms or a phenyl group unsubstituted or substituted by an alkyl group containing from 1 to 3 carbon atoms, R.sup.3 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 3 carbon atoms, and n represents 4 or 5) and cyclodextrin clathrates of such acids and esters and, when R represents a hydrogen atom, non-toxic salts thereof.
These new compounds exhibit characteristic prostaglandin-like activities.

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