15,16-seco-19-nor progestins

Details 15,16-seco-19-nor progestins 15,16-seco-19-nor progestins

1994-05-13

1995-12-26

Kestler, Kimberly J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514656, 514680, 558427, 568326, A61K 31275, C07C 49215

Patent

active

054788625

ABSTRACT:
The invention is drawn to 17-oxo-15,16-seco-19-nor steroids which are useful as intermediates in the production of various 15,16-seco-19-nor progestins. These progestins display elevated progestational activity with a minimum of ancillary hormonal activity and are thus useful in the suppression of ovulation in the human female.

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M. A. Bielefeld et al., "An Analog of Doisynolic Acid, 3-Hydroxy-16,17-seco-16-norestra-1,3,5(10)-trien-17-oic Acid", J. Med. Chem. 12(1):192-195 (1969).
P. F. Sherwin et al., "Effects of Steroid D-Ring Modification on Suicide Inactivation and Competitive Inhibition of Aromatase by Analogues of Androsta-1,4-diene-3,17-dione", J. Med. Chem. 32(3):651-657 (1989).
G. Pincus et al., "Effects of Certain 19-Nor Steroids on Reproductive Processes in Animals", Science 124:890-(1956).
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