14715, a human fringe family member nucleic acids and uses...

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S350000, C435S193000, C435S325000, C435S252300, C435S254110, C435S320100, C435S069100, C435S069700, C536S023100, C536S023500, C536S023400

Reexamination Certificate

active

06962811

ABSTRACT:
The invention provides isolated nucleic acids molecules, designated 14715 nucleic acid molecules, which encode novel fringe family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 14715 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 14715 gene has been introduced or disrupted. The invention still further provides isolated 14715 proteins, fusion proteins, antigenic peptides and anti-14715 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

REFERENCES:
patent: 2002/0042386 (2002-04-01), Rosen et al.
patent: 2003/0059875 (2003-03-01), Rosen et al.
patent: WO 01/57190 (2001-08-01), None
patent: WO 01/77291 (2001-10-01), None
patent: WO 02/18544 (2002-03-01), None
patent: WO 02/072830 (2002-09-01), None
Shimizu et al., Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation, J. Biol. Chem., 276(28):25753-58, Jul. 13, 2001.
Hicks et al., Fringe differential modulates Jagged1 and Delta1 signalling through Notch1 and Notch2, Nat. Cell Biol., 2:515-520, Aug. 2000.
Johnston, Stuart H., et al., “A Family of Mammalian Fringe Genes Implicated in Boundary Determination and the Notch Pathway”, Development 124:2245-2254 (1997).
Moran, Jennifer L., et al., “Genomic Structure, Mapping, and Expression Analysis of the Mammalian Lunatic, Manic, and Radical Fringe Genes”, Mammalian Genome 10:535-541 (1999).
Yu, W., et al., “Homo SapiensClone 23701 mRNA sequence.”, Jan. 22, 1998 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Aug. 7, 2004]. Retrieved from the internet: URL:http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. AF038196.
Johnston, S. H., et al., “Human Radical Fringe mRNA, partial cds.”, Jun. 19, 1997 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Aug. 7, 2004]. Retrieved from the internet: URL:http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. U94353.
Johnston, S. H., et al., “Radical Fringe [Homo Sapiens]”, Jun. 19, 1997 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Aug. 7, 2004]. Retrieved from the Internet: URL:http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. AAC51359.
Johnston, S. H., et al., “Beta-1, 3-N-Acetylglucosaminyltransferase Radical Fringe (O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase)”, Sep. 15, 2003 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Aug. 7, 2004]. Retrieved from the Internet: URL:http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. Q9Y644.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

14715, a human fringe family member nucleic acids and uses... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 14715, a human fringe family member nucleic acids and uses..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 14715, a human fringe family member nucleic acids and uses... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3521950

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.