14094, a novel human trypsin family member and uses thereof

Details 14094, a novel human trypsin family member and uses thereof 14094, a novel human trypsin family member and uses thereof

2006-07-04

2006-07-04

Yu, Misook (Department: 1642)

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

C436S518000, C435S007100, C435S007800

Reexamination Certificate

active

07071004

ABSTRACT:
The invention provides isolated nucleic acids molecules, designated 14094 nucleic acid molecules, which encode a novel trypsin family member. Elevated expression of 14094 mRNA was detected in breast, ovarian, lung, and liver cancers compared to normal cells derived from these tissues. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 14094 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 14094 gene has been introduced or disrupted. The invention still further provides isolated 14094 proteins, fusion proteins, antigenic peptides and anti-14094 antibodies. Therapeutic and diagnostic methods utilizing compositions of the invention to, for example, treat, prevent, and/or diagnose neoplastic conditions, are also provided.

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