14-Methoxymorphinan-6-one compounds and therapeutic methods of t

Details 14-Methoxymorphinan-6-one compounds and therapeutic methods of t 14-Methoxymorphinan-6-one compounds and therapeutic methods of t

1979-04-24

1981-06-09

Sutto, Anton H.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546 74, A61K 31485, C07D22128

Patent

active

042725402

ABSTRACT:
Disclosed are 14-methoxy substituted 3-hydroxy or 3-methoxy -6-one morphinans characterized by the structural formula: ##STR1## wherein R is H or methyl; R.sub.1 is H, .alpha. methyl or .beta. methyl; and R.sub.2 is cyclobutylmethyl, cyclopropylmethyl, tetrahydrofurfuryl or dimethylallyl. The compounds of the present invention are variously useful as analgesics, narcotic antagonists and mixed analgesics
arcotic antagonists.

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Posner, "Conjugate Addition Reactions of Organocopper Reagents", Organic Reactions, vol. 19, pp. 1-114 (1972).
Monkovic, et al., Chemical Abstracts, vol. 83,193565H (1975).
Fleischhacker, et al., Chemical Abstracts, vol. 77,152408s (1972).

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