14-hydroxy-N-(2-methoxyethyl)-7,8-dihydromorphine and -norisomor

Details 14-hydroxy-N-(2-methoxyethyl)-7,8-dihydromorphine and -norisomor 14-hydroxy-N-(2-methoxyethyl)-7,8-dihydromorphine and -norisomor

1992-09-25

1993-08-31

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 44, C07D48908, A61K 31485

Patent

active

052409333

ABSTRACT:
The present invention relates to 14-hydroxy-N-(2-methoxyethyl)-7,8-dihydromorphine and -norisomorphine, processes for preparing them and their use as pharmaceutical compositions.

REFERENCES:
Ronai et al, The Journal of Pharmacology & Experimental Therapeutics (vol. 200 Jan.-Mar. 1977) "Orientation of the Oxygen Atom at C-6 as a Determinant of Agonistic Activity in the Oxymorphone Series".
Pollock, Life Sciences (vol. 17, pp. 465-476) "Dihydromorphinone Ketone Reductases".
Chatterjie et al. Journal of Medicinal Chemistry (vol. 18, No. 5, May 1975) "Stereospecific Synthesis of the 6.beta.-Hydroxy Metabolites of Naltrexone and Naloxone".
Malspeis et al. Research Communications in Chemical Pathology and Pharmacology (vol. 12, No. 1, Sep. 1975) "Metabolic Reduction of Naltrexone I. Synthesis, Separation & Characterization of Naloxone and Naltrexone Reduction Products & Qualitative Assay of Urine and Bile Following Administration of Naltrexone, .alpha.-Naltrexol, or .beta.-Naltrexol".
Hahn et al. The Journal of Organic Chemistry (vol. 40, No. 1, Jan. 1975) "Narcotic Antagonists. V. Stereochemisry of Reactions at C-6 in 14-Hydroxynoroxymorphone Derivatives".
Chemical Abstracts (vol. 62, No. 5, Mar. 1965) Abstract No. 5308h "Derivatives of Morphine. IV. 14-Hydroxymorphine and 14-Hydroxydihydromorphine".

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