14-Hydroxy-6-oxamorphinans and 14-hydroxy-6-oxaisomorphinans

Details 14-Hydroxy-6-oxamorphinans and 14-hydroxy-6-oxaisomorphinans 14-Hydroxy-6-oxamorphinans and 14-hydroxy-6-oxaisomorphinans

1979-02-28

1980-10-14

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424256, 424260, 546 15, C07D49118, A61K 31435

Patent

active

042282853

ABSTRACT:
14-Hydroxy-6-oxamorphinans and 14-hydroxy-6-oxaisomorphinans optionally substituted in the 3-, 7- and 17-positions have been found to possess potent analgetic, narcotic antagonist, antitussive and/or ADH inhibitory activity. The compounds are prepared by total synthesis and are not derived from opium alkaloids.

REFERENCES:
patent: 3819635 (1974-06-01), Pachter
patent: 3853889 (1974-12-01), Monkovic et al.
patent: 3959290 (1976-05-01), Monkovic et al.
patent: 4016167 (1977-04-01), Montzka et al.
Lambert et al., Chem. Abs. 88, 62495r (1977).

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