14-halo-camptothecins

Details 14-halo-camptothecins 14-halo-camptothecins

1994-12-02

1995-10-17

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49122

Patent

active

054592690

ABSTRACT:
A method of making racemic DE ring intermediates for the synthesis of camptothecin and camptothecin analogs employing novel intermediates of Formula (XX) and (XXI): ##STR1## wherein R.sub.20 is loweralkyl, R is loweralkyl, Y is H or halogen, and R.sub.21 is loweralkoxy; as precursors to the DE ring intermediate.
The present invention also provides a camptothecin analog of Formula (I-A): ##STR2## wherein: Hal is a halogen;

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