14-EPI-19-nor-vitamin D compounds and methods

Details 14-EPI-19-nor-vitamin D compounds and methods 14-EPI-19-nor-vitamin D compounds and methods

1998-06-11

1999-08-10

Clardy, S. Mark

Organic compounds -- part of the class 532-570 series

Organic compounds

9,10-seco-cyclopentanohydrophenanthrene ring system or...

C07C40100

Patent

active

059361050

ABSTRACT:
19-nor-vitamin D analog compounds and a method of synthesizing such compounds are disclosed. More particularly, examples of such compounds include 14-epi-19-nor-1.alpha.,25-dihydroxyvitamin D.sub.3, 14-epi-20-epi-19-nor-1.alpha., 25-dihydroxyvitamin D.sub.3, 14-epi-20-epi-19-nor-1.alpha.-hydroxyvitamin D.sub.3, 14-epi-19-nor-1.alpha., 25-dihydroxyvitamin D.sub.2, 14-epi-19-nor-24-homo-1.alpha., 25-didydroxyvitamin D.sub.3, 14-epi-19-nor-20(S)-hydroxymethyl-1.alpha.-hydropregnacalciferol, and 14-epi-19-nor-20(R)-hydroxymethyl-1.alpha.-hydroxypregnacalciferol.

REFERENCES:
patent: 5391755 (1995-02-01), DeLuca
patent: 5843928 (1998-12-01), Deluca et al.

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