14-Aminodaunomycins, their preparation and use

Details 14-Aminodaunomycins, their preparation and use 14-Aminodaunomycins, their preparation and use

1975-12-03

1977-05-17

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 4, 536 17, C07H 1522, A61K 3171

Patent

active

040242242

ABSTRACT:
14-Aminodaunomycins, which are prepared by reacting 14-bromodaunomycin with an amine in a solvent at about 20.degree.-60.degree. C. are useful in treating certain tumors such as ascites Sarcoma 180 and solid Sarcoma 180.

REFERENCES:
patent: 3037015 (1962-05-01), Rudy et al.
patent: 3133912 (1964-05-01), Kimmig et al.
patent: 3803124 (1974-04-01), Arcamone et al.
patent: 3957755 (1976-05-01), Jolles
Noller, "Chem. of Organic Compounds," 3rd Ed., W. B. Saunders Co., Phila. Pa., 1965, pp. 252 and 253.

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