14-Amino derivatives of morphine, methods of making them and ana

Details 14-Amino derivatives of morphine, methods of making them and ana 14-Amino derivatives of morphine, methods of making them and ana

1978-03-15

1980-12-23

Tovar, Jose

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546 44, 546 45, 542403, A61K 31485, C07D48906

Patent

active

042410673

ABSTRACT:
Novel derivatives of morphine having the general formula: ##STR1## wherein R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are certain specified values, and their pharmaceutically acceptable salts.
The compounds exhibit activity in the central nervous system and may be presented in the form of pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable salt thereof, in association with a pharmaceutically acceptable diluent or carrier.

REFERENCES:
patent: 3819635 (1974-06-01), Pachter et al.
patent: 4017497 (1977-04-01), Lim et al.
Bentley et al., Chemical Communications, (1969), p. 1411.
Allen et al., Chemical Communications, (1970), p. 1346.
Fieser et al., "Reagents for Organic Synthesis", John Wiley & Sons, N.Y. (1967), pp. 1081-1082.
Joshi et al., Chemical Abstracts, vol. 43, 7438c(1949).
Arnold, Chemical Abstracts, vol. 78, 98250q (1973).
Allen; R. M., "Synthesis of New Codeinone and Indolinocodeinone Derivatives", Thesis submitted to Loughborough University of Technology, 9/71, cited in Index to Theses, vol. XXII, 1971-1972, ed Paterson et al., Aslib, London (1974).
Rice, Journal of Medicinal Chemistry, vol. 20, No. 1, pp. 164-165, (1/77).

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