14.alpha.-hydroxy-4-androstene-3,6,17-trione hydrate crystal and

Details 14.alpha.-hydroxy-4-androstene-3,6,17-trione hydrate crystal and 14.alpha.-hydroxy-4-androstene-3,6,17-trione hydrate crystal and

1994-05-23

1997-03-25

Cook, Rebecca

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

435 60, C07J 100

Patent

active

056146515

ABSTRACT:
Provided are stable hydrate crystals of 14.alpha.-hydroxy-4-androstene-3,6,17-trione having a biological activity of human placenta-originating estrodiene synthesis enzyme inhibitory action. These hydrate crystals include two kinds of 14.alpha.-hydroxy-4-androstene-3,6,17-trione hydrate crystals having a diffraction pattern having characteristic peaks at diffraction angles in crystalline powder X-ray diffraction. Processes for producing these hydrate crystals are also provided.

REFERENCES:
patent: 4975368 (1990-12-01), Yoshihama et al.
patent: 5098535 (1992-03-01), Nakakoshi et al.
Remmington's Pharmaceutical Sciences, 15th edition, 1975, p. 1358.

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