14-.alpha.,17-.alpha.-C.sub.2 -bridged norprogesterone derivativ

Details 14-.alpha.,17-.alpha.-C.sub.2 -bridged norprogesterone derivativ 14-.alpha.,17-.alpha.-C.sub.2 -bridged norprogesterone derivativ

1998-08-18

1999-10-26

Dees, Jose' G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

540 15, 540 16, 540 60, 540 62, C07J 5300, C07J 7100

Patent

active

059731729

ABSTRACT:
The invention describes 14,17-C.sub.2 -bridged steroids of general formula (I), ##STR1## wherein the various R groups are as defined in the specification, and wherein said steroids are in contrast, with the disclaimed compound, the new compounds are available even after peroral administration with high gestagenic action and are suitable for the production of pharmaceutical agents.

REFERENCES:
A.J. Solo et al., Steroids: Structure, Function and Regulation, 18:251-259 (Sept. 1971).
A.J. Solo et al., Journal of Medicinal Chemistry, 16:270-273 (Mar. 1973).
J.R. Bull et al., South African Journal of Chemistry, 44:87-94 (Sept. 1991).
A.J. Solo et al., Journal of Pharmaceutical Sciences, 62:1471-1475 (Sept. 1973).

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