14-acyloxy-2'-halo-anthracycline anti-cancer antibiotics

Details 14-acyloxy-2'-halo-anthracycline anti-cancer antibiotics 14-acyloxy-2'-halo-anthracycline anti-cancer antibiotics

1987-04-23

1988-09-20

Brown, J. R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1524

Patent

active

047726881

ABSTRACT:
Compounds of the formula (I) and pharmaceutical preparations containing the same are disclosed ##STR1## wherein R.sup.1 is --OOCR.sup.3 or --OOC(CH.sub.2).sub.n COOR.sup.4 ; R.sup.2 is hydrogen, hydroxy or methoxy; one of X and X' is a halogen atom selected from the group consisting of fluorine, chlorine, bromine and iodine and the other is hydrogen; one of Y and Y' is hydrogen and the other is selected from the group consisting of hydrogen, hydroxy and acyloxy; one of Z and Z' is hydrogen and the other is selected from the group consisting of hydrogen, hydroxy and acyloxy; R.sup.3 is an alkyl group containing 1 to 8 carbon atoms; R.sup.4 is a hydrogen atom, a metal atom, or an alkyl group containing 1 to 4 carbon atoms; and n is an integer of 0 to 6. These compounds are active in the inhibition of malignant diseases.

REFERENCES:
patent: 4427664 (1984-01-01), Hordon et al.
Arcamone et al., Journal of Medical Chemistry 1979, vol. 17, No. 3, pp. 335-337.

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