13245, a novel human myotonic dystrophy type protein kinase...

Details 13245, a novel human myotonic dystrophy type protein kinase... 13245, a novel human myotonic dystrophy type protein kinase...

2005-09-20

2005-09-20

Monshipouri, Maryam (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C435S006120, C435S252300, C435S320100, C435S325000, C536S023200

Reexamination Certificate

active

06946274

ABSTRACT:
The invention provides isolated nucleic acids molecules, designated 13245 nucleic acid molecules, which encode a novel myotonic dystrophy type protein kinase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 13245 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 13245 gene has been introduced or disrupted. The invention still further provides isolated 13245 proteins, fusion proteins, antigenic peptides and anti-13245 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

REFERENCES:
patent: WO 01/38503 (2001-05-01), None
“Human Protein Kinase and Protein Kinase-Like Enzymes”, Jun. 22, 2001 (sequence) srs@EMBL-EBI [online], Hinxton, Cambridge, UK: European Bioinformatics Institute [retrieved on May 22, 2002]. Retrieved from the Internet search of EMBL databank: EMBL Accession No. AX166567.
Madaule, P. et al., “Mus Musculus Citron, Putative rho/rac effector, mRNA, complete cds.” Dec. 30, 1995 [sequence] GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 31, 2005]. GenBank Accession No. U39904.
DiCunto, F. et al., “Mus Musculus rho/rac-interacting Citron Kinase (Crik) mRNA, complete cds.” Nov. 11, 1998 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 31, 2005]. Retrieved from the Internet: GenBank Accession No. AF086824.
Zhang, W. et al., “Rattus Norvegicus Postsynaptic Density Protein (Citron) mRNA, complete cds.” Jul. 2, 1998 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 31, 2005]. Retrieved from the Internet: GenBank Accession No. AF039218.
Nagase, T. et al., “Homo Sapiens mRNA for KIAA0949 Protein, Partial cds.” Jan. 28, 2005 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 31, 2005]. Retrieved from the Internet: URL: GenBank Accession No. AB023166.
“Oa56c11.r1 NCI_CGAP_GCB1 Homo Sapiens cDNA Clone IMAGE: 1308980 5′, mRNA sequence” Jan. 27, 1998 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 31, 2005]. Retrieved from the Internet: GenBank Accession No. AA746301.
Chahine, M. et al., “Myotonic Dystrophy Kinase Modulates Skeletal Muscle but not Cardiac Voltage-Gated Sodium Channels”, FEBS Letters 412:621-624 (1997).
Bush et al., “Myotonic dystrophy protein kinase domains mediate localization, oligomerization, novel catalytic activity, and autoInhibition,” Biochem. 39(29):8480-8490 (2000).
Dicunto et al., “Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the rho-rac-binding protein citron,” J. Biolog. Chem. 273(45):29706-29711 (1998).
Madaule et al., “A novel partner for the GTP-bound forms of rho and rac,” FEBS Letters 377:243-248 (1995).
Nagase et al., “Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro,” DNA Res. 6:63-70 (1999).
Zhao et al., “Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases,” J. Biolog. Chem. 272(15):10013-10020 (1997).
GenBank® Database, Accession No. AAC27933, Jul. 31, 1998.
GenBank® Database, Accession No. AAC72823, Nov. 10, 1998.
GenBank® Database, Accession No. O14578, May 30, 2000.
GenBank® Database, Accession No. P49025, May 30, 2000.
Matsui, Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein, Rho, Embo. J. 15(9):2208-2216, 1996 (Abstract only).
Madaule et al., Role of citron kinase as target of the small GT Pase Rho in cytokinesis, Nature 394(6692):491-494, 1998 (Abstract only).
Madaule et al., Citron, a Rho target that effects contractility during cytokines, Micros. Res. Tech. 49(2):123-126, 2000 (Abstract only).
Burbelo et al., A Conserved Binding Motif Defines Numerous Candidate Target Proteins For Both Cdc42 and Rac GTPases, J. Biol. Chem., 270(49):29071-29074, 1995.
Ferdinando et al., Citron Rho-interacting Kinase, a Novel Tissue-specific Ser/Thr Kinase Encompassing the Rho-Rac-binding Protein Citron, J. Biol. Chem., 273(45):29706-29711, 1998.
Fujisawa et al., Identification of the Rho-binding Domain of p160ROCK, a Rho-associated Coiled-coil Containing Protein Kinase, J. Biol. Chem., 271(38):23022-23028, 1996.

Affiliated with

Also associated with

Rating

13245, a novel human myotonic dystrophy type protein kinase... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 13245, a novel human myotonic dystrophy type protein kinase..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 13245, a novel human myotonic dystrophy type protein kinase... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3417496