13-Thiaprostaglandin derivatives

Details 13-Thiaprostaglandin derivatives 13-Thiaprostaglandin derivatives

1979-11-21

1982-01-05

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424308, 560 9, 560121, C07C17700, A61K 31557

Patent

active

043094414

ABSTRACT:
13-Thiaprostanoic acid derivatives of the general formula I ##STR1## wherein A is --CO-- or --CHOH--; B is --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--; Q is 1,4-phenylene or 1,4-naphthylene; R.sup.1 is H or OH; R.sup.2 is H or CH.sub.3 ; R.sup.3 is alkyl with 1-8 carbon atoms or alkyl with 1-8 carbon atoms substituted by (a) phenyl, (b) phenyl substituted by at least one of CH.sub.3, F, Cl, Br, OH, OCH.sub.3 or CF.sub.3 ; (c) phenoxy or (d) phenoxy substituted by at least one of CH.sub.3, F, Cl, Br, OH, OCH.sub.3 or CF.sub.3 ; and R.sup.4 is NH.sub.2, CH.sub.3, phenyl, p-acetylaminophenyl, p-benzoylaminophenyl or phenylamino. These compounds are useful for lowering blood pressure as well as for other pharmaceutical purposes. They also are useful intermediates for the preparation of other known pharmaceuticals such s the 13-thiaprostaglandins.

REFERENCES:
patent: 3894062 (1975-07-01), Morozowich
patent: 3931285 (1976-01-01), Morozowich
patent: 3932486 (1976-01-01), Morozowich
patent: 3932487 (1979-01-01), Kramer et al.
patent: 3994956 (1976-11-01), Morozowich
patent: 3998869 (1976-12-01), Morozowich
patent: 4080458 (1978-03-01), Radunz et al.

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