13-Sulfa-prostaglandins

Details 13-Sulfa-prostaglandins 13-Sulfa-prostaglandins

1973-11-15

1976-01-13

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603409, 260399, 260456P, 260464, 260470, 260485R, 260514D, 260516, 260557R, 260609R, 260609F, 424305, 424317, C07C14926, C07C14940

Patent

active

039324877

ABSTRACT:
Sulfides of the general formula ##SPC1##
Wherein R.sub.1 is H or alkyl, R.sub.2 is =O, (H,OH), or (H,lower-acyloxy), R.sub.3 is H, OH or lower-acyloxy, R.sub.4 is alkyl or alkyl substituted by F, OH, lower-acyloxy, phenyl or p-tolyl, and A is alkylene which can be mono- or polysubstituted by F, and the physiologically acceptable salts thereof, possess, in addition to a blood-pressure-lowering activity, prostaglandin-type and antiprostaglandin-type effects.

REFERENCES:
patent: 3749741 (1973-07-01), Strike et al.
patent: 3776940 (1973-12-01), Just et al.
Fried et al., Ann. N.Y. Acad. Sci., 180, 38 (1971).
Schaf et al., J. OC., 37, 2921 (1972).
Nakano, Prostaglandins, pp. 21-28 (1973).

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