13-substituted milbemycin 5-oxime derivatives, their preparation

Details 13-substituted milbemycin 5-oxime derivatives, their preparation 13-substituted milbemycin 5-oxime derivatives, their preparation

1996-09-30

1999-01-19

Owens, Amelia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514183, 514274, 514338, 514321, 514369, 514376, 514422, 514444, 549264, 549 60, 544316, 548187, 548229, 548526, 548952, 546197, 5462817, 5462831, A61K 31335, A61K 3138, A61K 31505, A61K 31425

Patent

active

058614290

ABSTRACT:
Compounds of formula (I): ##STR1## wherein: R.sup.1 is methyl, ethyl, isopropyl or sec-butyl; X is carbonyl or methylene; Z is .dbd.C.dbd.(R.sup.2).sub.2 or .dbd.C.dbd.(CH.sub.2).sub.m, in which R.sup.2 is alkyl, and m is integer of from 2 to 5); n is 0 or 1; R.sup.3 is nitro, amino, alkylamino, dialkylamino, alkoxy, alkoxyalkoxy, or a group (iii), (iv), (v), (vi), (vii), (viii) or (ix): ##STR2## , wherein: R.sup.4 represents: alkyl; substituted alkyl; cycloalkyl having from 3 to 6 carbon atoms; substituted cycloalkyl; alkenyl; alkynyl; carbocyclic aryl; or heterocyclic; R.sup.5 is hydrogen atom or alkyl; R.sup.6 represents: hydrogen; alkyl; or cycloalkyl; R.sup.7 represents: alkyl; cycloalkyl; carbocyclic aryl; or aralkyl; or R.sup.6 and R.sup.7, together with the nitrogen atom to which they are attached, are fuised to form heterocyclic ring; Y is oxygen or sulfur; r is 1, 2 or 3; Q is methylene or carbonyl; R.sup.8 is: alkyl or carbocyclic aryl; R.sup.9 is: alkyl; cycloalkyl; carbocyclic aryl; or aralkyl; R.sup.10 is heterocyclic; and R.sup.11 is aLkyl; have valuable acaricidal, insecticidal and anthelmintic activities.

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Database WPI, Section Ch, Week 9627, Derwent Publications Ltd., London, GB; Class B02, AN 96-268520, XP002020775, 9 616 064 (Sankyo Co Ltd), 30 May 1966 of WO 96 16064 A (Sankyo Company Ltd) 30 May 1996.

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