13-Halomilbemycin derivatives, their preparation and composition

Details 13-Halomilbemycin derivatives, their preparation and composition 13-Halomilbemycin derivatives, their preparation and composition

1988-12-28

1990-07-31

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549264, 549214, 536 71, 514 30, 514 63, A61K 31364, C07D31300

Patent

active

049451057

ABSTRACT:
Derivatives of milbemycins D, A.sub.3 and A.sub.4 and of the corresponding sec-butyl compound have a halogen atom at the 13-position; at the 5-position, they have an oxygen (keto) atom, an oxime group or a substituted oxime group. They may be prepared from known compounds by any appropriate combination of halogenation, ketonization and oximation.

REFERENCES:
patent: Re32034 (1985-11-01), Chabala et al.
patent: 3950360 (1976-04-01), Aoki et al.
patent: 4134973 (1979-01-01), Fisher et al.
patent: 4156720 (1979-05-01), Fisher et al.
patent: 4173571 (1979-11-01), Chabala et al.
patent: 4346171 (1982-08-01), Takiguchi et al.
patent: 4423209 (1983-12-01), Mrozik
patent: 4547520 (1985-10-01), Ide et al.
H. Mrozik et al, Tetrahedron Letters, vol. 24(48) (1983), pp. 53333-53336.

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