Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1977-12-19
1979-10-16
Trousof, Natalie
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
424279, 536 17A, C07D49322
Patent
active
041713141
ABSTRACT:
Derivatives of the C-076 compounds are disclosed wherein the 13-position is unsubstituted or substituted by a halogen atom. The compounds are prepared by removing the glycosyl groups on the 13-position of the C-076 compounds isolated from the fermentation broth of Streptomyces avermitilis. This is followed by substitution of the 13-hydroxy group with a halogen, and subsequent removal of the halogen. The disclosed compounds are antiparasitic, anthelmintic, insecticidal and acaracidal agents.
REFERENCES:
patent: 3950360 (1976-04-01), Aoki et al.
Mishima et al., Tetrahedron Letters 10, pp. 711-714 1975.
Journal of Antibiotics 29(6), Jun. 1976, pp. 76-35 to 76-42 and pp. 76-14 to 76-16.
Derwent Abstract 76268w/46 to Sankyo Co.
Chabala John C.
Fisher Michael H.
Mrozik Helmut H.
Fan Jane T.
Merck & Co. , Inc.
Rose David L.
Trousof Natalie
Westlake Harry E.
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