13,14-Didehydro-PGF, compounds

Details 13,14-Didehydro-PGF, compounds 13,14-Didehydro-PGF, compounds

1976-12-29

1978-08-15

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260410, 2604105, 2604109R, 260413, 260514D, 560121, C07C17700

Patent

active

041071913

ABSTRACT:
This invention comprises certain analogs of the prostaglandins in which the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
Burger, Medicinal Chem., pp. 81, 82, (1960).

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