13,14-Didehydro-PG analogs

Details 13,14-Didehydro-PG analogs 13,14-Didehydro-PG analogs

1976-02-13

1977-06-14

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260240R, 2603432R, 2603433R, 2603452, 2603457, 2603458, 2603462R, 2603473, 2603474, 260410, 2604105, 2604109R, 260413, 2604488R, 260468D, 260473A, 260473G, 260514D, 260520B, 260520C, 424305, 424308, 424317, C07C17700

Patent

active

040296814

ABSTRACT:
This invention comprises certain analogs of the prostaglandins in which the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
fried et al. Proc. Nat. Acad. Sci. 70 1579 (1973).

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