13, 14 Dehydro PGF.sub.3 compounds

Details 13, 14 Dehydro PGF.sub.3 compounds 13, 14 Dehydro PGF.sub.3 compounds

1976-11-18

1978-03-21

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2604109R, 260413, 260514D, 560121, C07C17700

Patent

active

040803732

ABSTRACT:
This invention comprises certain analogs of the prostaglandins in which the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin and analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
patent: 4013695 (1977-03-01), Lin
Fried et al., J. Med. Chem. 16, 429 (1973).
Cooper et al., Proc. Nat. Acad. Sci., 70, 1579 (1973).

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