12-Halogenated forskolin derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

549389, 514913, A61K 3135, C07D31192

Patent

active

048717649

ABSTRACT:
Novel 12-halogenated forskolin derivatives, intermediates and processes for their preparation, and methods for reducing intraocular pressure utilizing the compounds or compositions are disclosed.

REFERENCES:
patent: 4134986 (1979-01-01), Bajwa et al.
patent: 4476140 (1984-10-01), Sears et al.
patent: 4517200 (1985-05-01), Kreutner et al.
patent: 4639443 (1987-01-01), Kosley, Jr. et al.
patent: 4639446 (1987-01-01), Kosley, Jr. et al.
patent: 4677103 (1987-06-01), Kosley, Jr. et al.
Caprioli et al., "Forskolio Lowers Intraocular Pressure by Reducing Aqueous Inflow" in Invest. Ophthalmol. Vis. Sci., 25, 268, (1984).

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