11a-Methano-TXA compounds

Details 11a-Methano-TXA compounds 11a-Methano-TXA compounds

1979-05-01

1980-08-19

Niebling, John F.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260410, 2604105, 2604109R, 260413, 260408, 556416, 2603265D, 260239B, 260239BF, 542416, 542421, 544147, 544376, 546269, 546207, 560 51, 560 53, 560126, 562452, 562459, 562463, 562472, 562507, 562508, 568329, 568377, C07D30100, C07D30300, C09F 508, C11C 100

Patent

active

042183782

ABSTRACT:
The present invention provides novel 11a-methano-TXA compounds and intermediates and processs for their preparation. Further provided are methods for using these novel TXA analogs as inhibitors of thromboxane synthetase, rendering these analogs useful for a variety of pharmacological purposes. These pharmacological uses include anti-inflammatory, anti-thromobitc, and anti-asthma indications.

REFERENCES:
patent: 4107427 (1978-08-01), Kelly
Samuelson, B. et al., edt., Advances in Prostaglandin and Thromboxane Research (New York), p. 5.

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