11β-hydroxysteroid dehydrogenase type 1 active compounds

Details 11β-hydroxysteroid dehydrogenase type 1 active compounds 11β-hydroxysteroid dehydrogenase type 1 active compounds

2007-06-28

2011-11-01

Young, Shawquia (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S426000, C514S428000, C548S577000

Reexamination Certificate

active

08048908

ABSTRACT:
The use of substituted amides for modulating the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, of the general formula I. Their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11βHSDI and may be useful in the treatment of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.

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